Nuclear factor erythroid 2-related factors 2 (Nrf2) is a member of a basic lucine zipper (bZIP)
transcription factor protein family. Nrf2 positively regulates expression of detoxifying enzyme genes at the transcription level by directly binding to the antioxidant response element (ARE). Many of these genes encode proteins involved in response to injury, inflammation and cancer. Because of antioxidant and detoxification capability in cancer cells, high levels of Nrf2 activity enhance therapeutic resistance of cancer cells. Thus, Nrf2 inhibition has been becoming a promising strategy for cancer therapy. Recombinant human Nrf2 was expressed in E coli and purified by the combination of Ni-affinity and conventional/FPLC methods to >95% homogeneity. It has been tested for the AREcontaining dsDNA binding assay.
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