The human brahma-related gene 1 (BRG1/SMARCA4/BAF190) is a catalytic subunit of SWI/SNF
complexes that regulate transcription by mediating ATP-dependent chromatin remodeling
processes. Mutation of lysine residue 798 un the DNA dependent ATase domain significantly
reduced its ability to repress c-fos transcription. Recombinant BRG1 (K798R) was produced in Sf9 cells with a 6His tag at the N-terminus. The mutant K798R was originally created for yeast BRG1 (accession# P22082), which corresponds to human BRG1 K785R as indicated (Laurent et al., 1993,Genes & Dev 7, 583-591).
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