AscentGene is now offering purified Clostridium difficile spore proteins for research and vaccine development.

AscentGene is proud to announce the addition of five recombinant C. difficile proteins for research and vaccine development.

Clostridium difficile is a spore-forming and Gram-positive organism that is the leading cause of
antibiotic-associated infectious diarrhea, commonly know as C. difficile infection (CDI).

C. difficile spore proteins play important role in the germination, colonization and persistence of C. difficile in the human gut.

All five spore proteins available in our inventory were identified from the strain of C.
difficile 630, expressed in E coli and purified with endotoxin free.

FliC (CD0239) is a flagellin structural protein involved in the attachment of the organism to host cellsand important in the course of CDI.

CotA (CD1613) is a spore coat protein involved in spore coat morphogenesis.

BclA1 (CD0332) is a spore exosporium cysteine-rich protein and plays a role in the pathogenesis of C. difficile.

CdeC (CD1067) is a spore exosporium cysteine-rich protein and essential for exosporium
morphogenesis and assembly of the spore coat of C. difficile.

CdeM (CD1581) is a small cysteine-rich spore exosporium protein and may play a role in colonization and persistence of C. difficile.